A Single Platform that Accommodates the Pharmacometrics Toolkit – Challenging But Achievable
The current pharmacometric (PMx) toolkit has been expanding with newer tools an capabilities (Figure 1)
The existing tools are not necessarily being replaced by the emerging technologies but are rather complemented in some cases.
A user may want to employ several tools within a single analysis necessitating an infrastructure that allows utilizing multiple tools in the same computation environment
Any system devised must meet regulatory requirements around validation and compliance.
Additionally, the setup should allow elastic capacity, parallelization and grid support (e.g. slurm or grid engine).
Lastly, its critical to engage stakeholders i.e. non-PMx matrix team members in real time in an interactive system without getting deeply involved in model related technical details (e.g. RSHINY).